195514-80-8

中文名称 AP 20187

英文名称 AP20187

CAS 195514-80-8

分子式 C82H107N5O20

分子量 1482.75

MOL 文件 195514-80-8.mol

更新日期 2024/07/12 22:18:13

195514-80-8 结构式

基本信息物理化学性质图谱信息 AP 20187价格(试剂级) 常见问题列表

基本信息

中文别名

化合物AP20187

英文别名

AP20187
B/B Homodimerizer
AP20187 (AP-20187
AP20187
AP-20187
AP 20187
(1R,1'R)-(((((2-((dimethylamino)methyl)propane-1,3-diyl)bis(azanediyl))bis(2-oxoethane-2,1-diyl))bis(oxy))bis(3,1-phenylene))bis(3-(3,4-dimethoxyphenyl)propane-1,1-diyl) (2S,2'S)-bis(1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate)
(1R)-3-(3,4-dimethoxyphenyl)-1-[3-[2-[[2-[[[2-[3-[(1R)-3-(3,4-dimethoxyphenyl)-1-[(2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetyl]amino]methyl]-3-(dimethylamino)propyl]amino]-2-oxoethoxy]phenyl]propyl] (2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carboxylate

所属类别

生物化工：激动剂抑制剂

物理化学性质

沸点1333.5±65.0 °C(Predicted)

密度1.192±0.06 g/cm3(Predicted)

储存条件Store at -20°C,protect from light

溶解度≥74.14 mg/mL in DMSO; ≥100 mg/mL in EtOH

酸度系数(pKa)13.97±0.46(Predicted)

形态固体

颜色White to yellow

图谱信息

AP 20187(195514-80-8)质谱(MS)

AP 20187价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/04/30	HY-13992	AP 20187 AP20187	195514-80-8	5mg	2700元
2024/04/30	HY-13992	AP 20187 AP20187	195514-80-8	10mg	4300元
2024/04/30	HY-13992	AP 20187 AP20187	195514-80-8	10mM * 1mLin DMSO	7013元

常见问题列表

生物活性

AP20187 (B/B Homodimerizer) 是一种细胞渗透性分子，使 FK506 结合蛋白 (FKBP) 二聚化，启动生物信号传导级联反应和基因表达，或破坏蛋白-蛋白之间相互作用。

靶点

FKBP homodimerizer

体外研究

When LNCaP cells are treated with AP20187 (B/B Homodimerizer) (100 nM), ro-iCaspase-9 levels are significantly reduced, and the smaller processed active caspase-9 becomes apparent.

体内研究

Real-time PCR analysis shows that AP20187 (B/B Homodimerizer) (0.5 mg/kg, 2 mg/kg, or 5 mg/kg) treatment significantly increases the levels of CHOP mRNA in the CNS of PLP/Fv2E-PERK mice at PID12. AP20187 treatment significantly alleviates EAE-induced myelin damage in these mice. AP20187 (B/B Homodimerizer) treatment significantly reduces the number of degenerating axons and increases the density of axons in the demyelinating lesions in the lumbar spinal cord of PLP/Fv2E-PERK mice.