1956343-52-4
中文名称
化合物 T34892
英文名称
TM608
CAS
1956343-52-4
分子式
C43H37BrCl2N3O4PS
分子量
873.62
MOL 文件
1956343-52-4.mol
1956343-52-4 结构式
应用领域
用途一
TM608 is a potent and selectiv c-MET inhibitor which targets Mitochondrial and Kills Erlotinib-Resistant Lung Cancer Cells. TM608 is the first TPP-TKI conjugate, can rapidly accumulates in mitochondria and suppresses the activation of MET in high MET expressing, erlotinib-resistant HCC827B cells (total cell lysates and mitochondrial fractions). TM608 was as potent and apoptogenic as PHA665752 in abrogating NSCLC cell viability. Directed accessibility to the mitochondria as afforded by a targeting moiety like TPP could conceivably compensate for deficient activity if uptake is rapid, cumulative, and selective.