195875-69-5

中文名称化合物 T26364

英文名称 8-Azabicyclo[3.2.1]octane, 3-(3,4-dichlorophenyl)-2-(methoxymethyl)-8-methyl-, (1R,2R,3S,5S)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:)

CAS 195875-69-5

分子式 C22H29Cl2NO8

分子量 506.37

MOL 文件 195875-69-5.mol

195875-69-5 结构式

基本信息应用领域

基本信息

中文别名

化合物 T26364

英文别名

GSK372475
GSK 372475
GSK-372475
NS-2359 citrate
8-Azabicyclo[3.2.1]octane, 3-(3,4-dichlorophenyl)-2-(methoxymethyl)-8-methyl-, (1R,2R,3S,5S)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:)

应用领域

用途一

NS-2359 is a serotonin-norepinephrine-dopamine reuptake inhibitor. It was under development by GlaxoSmithKline (GSK) as an antidepressant, but was discontinued in 2009 when phase II clinical trials turned up disappointing results and did not support further effort by the company. NS-2359 was also in clinical trials for the treatment of ADHD, phase II having been completed in 2007. A trial exploring the effect of NS-2359 on cocaine-experienced individuals is currently ongoing.