1979939-16-6
中文名称
3H-Imidazo[4,5-b]pyridine-2-propanamide, N-[(1S)-1-(4-chlorophenyl)ethyl]-3-[[4-(trifluoromethoxy)phenyl]methyl]-
英文名称
3H-Imidazo[4,5-b]pyridine-2-propanamide, N-[(1S)-1-(4-chlorophenyl)ethyl]-3-[[4-(trifluoromethoxy)phenyl]methyl]-
CAS
1979939-16-6
分子式
C25H22ClF3N4O2
分子量
502.92
MOL 文件
1979939-16-6.mol
1979939-16-6 结构式
基本信息
中文别名
化合物CRT0273750CRT0273750
CRT 0273750
CRT-0273750
英文别名
CRT02737503H-Imidazo[4,5-b]pyridine-2-propanamide, N-[(1S)-1-(4-chlorophenyl)ethyl]-3-[[4-(trifluoromethoxy)phenyl]methyl]-
物理化学性质
沸点680.4±55.0 °C(Predicted)
密度1.35±0.1 g/cm3(Predicted)
溶解度DMSO: Soluble
酸度系数(pKa)14.92±0.46(Predicted)
形态A solid
颜色White to off-white
应用领域
用途一
CRT0273750 is an autotaxin inhibitor. CRT0273750 modulates LPA levels in plasma and is suitable for in vivo studies. CRT0273750 has an unexpected binding mode in that they do not interact with the active site zinc ions but instead occupy the hydrophobic LPC pocket extending from the active site of ATX together with occupying the LPA 'exit' channel.