198062-54-3

中文名称 CS-1261

英文名称 (3S,3AS,6AR)-3-ISOPROPYL-1-(METHANESULFONYL)-4-[4-(1-PIPERIDINYL)-2(E)-BUTENOYL]PERHYDROPYRROLO[3,2B]PYRROL-2(1H)-ONE HYDROCHLORIDE

CAS 198062-54-3

分子式 C19H31N3O4S

分子量 397.53

MOL 文件 198062-54-3.mol

更新日期 2023/03/20 15:41:23

198062-54-3 结构式

基本信息物理化学性质安全数据 CS-1261价格(试剂级) 常见问题列表

基本信息

中文别名

化合物 T11525

英文别名

CS-1261
GW311616
GW311616A
GW311616HCl
GW 311616 HYDROCHLORIDE
(3S,3aS,6aR)-Hexahydro-3-(1-methylethyl)-1-(methylsulfonyl)-4-((2E)-1-oxo-4-(1-piperidinyl)-2-butenyl)pyrrolo[3.2-b]pyrr
(3S,3AS,6AR)-3-ISOPROPYL-1-(METHANESULFONYL)-4-[4-(1-PIPERIDINYL)-2(E)-BUTENOYL]PERHYDROPYRROLO[3,2B]PYRROL-2(1H)-ONE HYDROCHLORIDE
Pyrrolo[3,2-b]pyrrol-2(1H)-one, hexahydro-3-(1-methylethyl)-1-(methylsulfonyl)-4-[(2E)-1-oxo-4-(1-piperidinyl)-2-buten-1-yl]-, (3S,3aS,6aR)-
(3S,3AS,6AR)-HEXAHYDRO-3-(1-METHYLETHYL)-1-(METHYLSULFONYL)-4-[(2E)-1-OXO-4-(1-PIPERIDINYL)-2-BUTENYL]PYRROLO[3,2-B]PYRROL-2(1H)-ONE HYDROCHLORIDE

所属类别

生物化工：激动剂抑制剂

物理化学性质

沸点583.6±60.0 °C(Predicted)

密度1.27±0.1 g/cm3(Predicted)

储存条件2-8°C

溶解度H₂O: 24 mg/mL, soluble

酸度系数(pKa)8.53±0.10(Predicted)

形态solid

颜色Light brown to brown

安全数据

危险品标志Xi

危险类别码36/37/38

安全说明26-36

WGK Germany3

CS-1261价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/04/30	HY-15891	CS-1261 GW311616	198062-54-3	2mg	2190元
2024/04/30	HY-15891	CS-1261 GW311616	198062-54-3	5mg	3510元
2024/04/30	HY-15891	CS-1261 GW311616	198062-54-3	10mM * 1mLin DMSO	3861元

常见问题列表

生物活性

GW-311616 是高活性，口服生物相容性，长效的人中性白细胞弹性蛋白酶 (HNE) 抑制剂。IC50 为 22 nM，Ki 为 0.31 nM。

靶点

IC50: 22 nM (HNE) Ki: 0.31 nM (HNE)

体外研究

GW-311616 (150 μM; 48 hours) markedly suppresses NE activity in U937 and K562 cells lines.
GW-311616 (20-320 μM; 48 hours; U937 cells) treatment inhibits proliferation and induces apoptosis in leukemia cells.
GW-311616 (150 μM; U937 cells) treatment can increase the protein expression levels of Bax and decrease the expression of Bcl-2.

Cell Viability Assay

Cell Line:	U937 and K562 cells
Concentration:	150 μM
Incubation Time:	48 hours
Result:	Markedly suppressed NE activity.

Apoptosis Analysis

Cell Line:	U937 cells
Concentration:	20 μM, 40 μM, 80 μM, 160 μM, 320 μM
Incubation Time:	48 hours
Result:	The rate of apoptosis was enhanced.

Western Blot Analysis

Cell Line:	U937 cells
Concentration:	150 μM
Incubation Time:	48 hours
Result:	Increased the protein expression levels of Bax and decreased the expression of Bcl-2.

体内研究

GW-311616 (2 mg/kg; oral administration) rapidly abolishes the circulation of neutrophil elastase (NE) in dogs, while >90% inhibition is maintained for 4 days. This prolonged effect is independent to be due to penetration of neutrophils in bone marrow by orally administrated GW-311616. GW-311616 has moderate terminal elimination half-life (t _1/2 ) of 1.1 hours and 1.5 hours for dog (2 mg/kg, oral), rat (2 mg/kg, oral), respectively.

Animal Model:	Dogs (9-month-old)
Dosage:	0.22 mg/kg, 0.66 mg/kg and 2 mg/kg (Pharmacokinetic study)
Administration:	Oral administration
Result:	At 0.22 mg/kg, greater than 50% inhibition of elastase was achieved 6 hours after dosing, with activity returning towards control values. Single oral dose of 2 mg/kg rapidly abolished circulating enzyme activity, and greater than 90% inhibition was maintained for 4 days.