198284-64-9
198284-64-9 结构式
基本信息
缝隙连接蛋白多肽
GAP 27, >98%
GAP-27
GAP27
M.W. 1304.55 C60H101N15O17
Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile
Gap 27,Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile, >98%
H-SER-ARG-PRO-THR-GLU-LYS-THR-ILE-PHE-ILE-ILE-OHSER-ARG-PRO-THR-GLU-LYS-THR-ILE-PHE-ILE-ILE
L-Isoleucine, L-seryl-L-arginyl-L-prolyl-L-threonyl-L-α-glutamyl-L-lysyl-L-threonyl-L-isoleucyl-L-phenylalanyl-L-isoleucyl-
物理化学性质
常见问题列表
Gap 27 causes a remarked decrease in the number of both TRAP-positive mononuclear and multinucleated rat osteoclasts cultured on bovine bone slices. The activity of the remaining osteoclasts is found to be diminished by measuring the percentage of osteoclasts with actin rings of all TRAP-positive cells. In addition, the resorbed area in the treated cultures is greatly diminished. Incubation of the carotid artery with the gap junction inhibitor Gap 27 (500 μM) essentially abolishes the hyperpolarization to acetylcholine but it is without effect on that to levcromakalim. In the guinea-pig isolated internal carotid artery, Gap 27 inhibits acetylcholine-induced, endothelium-dependent hyperpolarizations.
Gap 27 (300 μM) inhibits relaxation by 40% in thoracic aorta and the superior mesenteric artery. Gap 27 also attenuates the endothelium-dependent component of the relaxation induced by ATP in thoracic aorta. .