199807-33-5
中文名称
199807-33-5
英文名称
Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA
CAS
199807-33-5
更新日期
2023/03/20 15:41:19
分子式
C28H39F3N8O9
分子量
688.66
MOL 文件
199807-33-5.mol
199807-33-5 结构式
常见问题列表
生物活性
Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) 是整合蛋白 αvβ3 的抑制剂，具有抗肿瘤活性。靶点
αvβ3
体外研究
Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) is an inhibitor of integrin αvβ3. Cyclo(Arg-Gly-Asp-D-Phe-Val) [c(RGDfV); 35 nM] induces disruption of leukemia cell migration and adhesion to leukemia osteoblasts in the 3D and 2D culture systems, affects the leukemia cell cycle and induces apoptosis in leukemia cells.