200803-37-8

中文名称 200803-37-8

英文名称 OSIP-486823

CAS 200803-37-8

分子式 C29H28FNO4

分子量 473.54

MOL 文件 200803-37-8.mol

更新日期 2023/03/20 15:41:17

200803-37-8 结构式

基本信息物理化学性质常见问题列表

基本信息

中文别名

化合物 T13807

英文别名

CP248
OSIP-486823
1H-Indene-3-acetamide, 5-fluoro-2-methyl-N-(phenylmethyl)-1-[(3,4,5-trimethoxyphenyl)methylene]-, (1Z)-

物理化学性质

沸点667.3±55.0 °C(Predicted)

密度1.206±0.06 g/cm3(Predicted)

储存条件-20°C储存

溶解度溶于二甲基亚砜

酸度系数(pKa)15.72±0.46(Predicted)

形态Solid

颜色Light yellow to yellow

常见问题列表

生物活性

OSIP-486823 是一种新型的微管干扰剂，对蛋白激酶 G (PKG) 和微管均具有生物学作用。

靶点

Microtubule

体外研究

OSIP486823 inhibits growth and induce apoptosis in SW480 human colon cancer cells, with IC ₅₀ of 0.1 μM. OSIP-486823 (OSIP486823) causes depolymerization of microtubules in interphase cells, inhibit spindle formation in mitotic cells, and induce multinucleated cells. Exisulind and the potent synthetic derivative OSIP-486823 are members of a new class of drugs known as selective apoptotic antineoplastic drugs that target cyclic guanosine 3′,5′-monophosphate phosphodiesterases (cGMP-PDE). OSIP-486823 also disrupts microtubule polymerization, perturbs mitotic spindle function, and arrests cells in mitosis in human glioma cells.