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200803-37-8

中文名称 200803-37-8
英文名称 OSIP-486823
CAS 200803-37-8
分子式 C29H28FNO4
分子量 473.54
MOL 文件 200803-37-8.mol
更新日期 2023/03/20 15:41:17
200803-37-8 结构式 200803-37-8 结构式

基本信息

中文别名
化合物 T13807
英文别名
CP248
OSIP-486823
1H-Indene-3-acetamide, 5-fluoro-2-methyl-N-(phenylmethyl)-1-[(3,4,5-trimethoxyphenyl)methylene]-, (1Z)-

物理化学性质

沸点667.3±55.0 °C(Predicted)
密度1.206±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)15.72±0.46(Predicted)
形态Solid
颜色Light yellow to yellow

常见问题列表

生物活性
OSIP-486823 是一种新型的微管干扰剂,对蛋白激酶 G (PKG) 和微管均具有生物学作用。
靶点

Microtubule

体外研究

OSIP486823 inhibits growth and induce apoptosis in SW480 human colon cancer cells, with IC 50 of 0.1 μM. OSIP-486823 (OSIP486823) causes depolymerization of microtubules in interphase cells, inhibit spindle formation in mitotic cells, and induce multinucleated cells. Exisulind and the potent synthetic derivative OSIP-486823 are members of a new class of drugs known as selective apoptotic antineoplastic drugs that target cyclic guanosine 3′,5′-monophosphate phosphodiesterases (cGMP-PDE). OSIP-486823 also disrupts microtubule polymerization, perturbs mitotic spindle function, and arrests cells in mitosis in human glioma cells.

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