201943-63-7
201943-63-7 结构式
基本信息
(ALPHAS)-ALPHA-氨基-ALPHA-[(1S,2S)-2-羧基环丙基]-9H-吨-9-丙酸
LY 341495
LY 341495
LY-341495
9H-Xanthene-9-propanoic acid, α-amino-α-[(1S,2S)-2-carboxycyclopropyl]-, (αS)-
(2S)-2-AMINO-2-[(1S,2S)-2-CARBOXYCYCLOPROP-1-YL]-3-(XANTH-9-YL) PROPANOIC ACID
(alphaS)-alpha-Amino-alpha-[(1S,2S)-2-carboxycyclopropyl]-9H-xanthene-9-propanoic acid
(1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl]cyclopropane-1-carboxylic acid
(alphaS)-alpha-Amino-alpha-[(1S,2S)-2-carboxycyclopropyl]-9H-xanthene-9-propanoic acid LY 341495
物理化学性质
常见问题列表
|
mGluR1a 7.8 μM (IC 50 ) |
mGluR2 21 nM (IC 50 ) |
mGluR3 14 nM (IC 50 ) |
mGluR4 22 μM (IC 50 ) |
mGluR5a 8.2 μM (IC 50 ) |
mGluR7 990 nM (IC 50 ) |
mGluR8 170 nM (IC 50 ) |
LY341495 (0.3, 1, and 3 mg/kg, i.p.) displays a lower level of discrimination in rats. LY341495 (3.0 mg/kg) decreases Dvl-2, pGSK-3α/β and β-catenin protein levels but Dvl-1, Dvl-3 and GSK-3α/β are unaffected in both the PFC and STR. LY341495 has the generally the opposite effect following acute and chronic administration compared to mGlu2/3 agonist, LY379268. LY341495 (3 mg/kg, i.p., 2.5 h) -induced c-Fos expression is not altered in either KO brain. LY341495 is almost inactive in the central extended amygdala [central nucleus of the amygdala, lateral (CeL) and bed nucleus of the stria terminalis, laterodorsal (BSTLD)] in mGluR3-KO mice.