2023788-32-9
中文名称
INTEGRIN MODULATOR 1
英文名称
2-Azetidineacetic acid, 1-[[(2-methylphenyl)amino]carbonyl]-4-oxo-
CAS
2023788-32-9
分子式
C13H14N2O4
分子量
262.26
MOL 文件
2023788-32-9.mol
更新日期
2023/03/20 15:41:27
2023788-32-9 结构式
物理化学性质
密度1.413±0.06 g/cm3(Predicted)
储存条件4°C, away from moisture and light
溶解度DMSO: 100 mg/mL (381.30 mM)
酸度系数(pKa)4.20±0.10(Predicted)
形态Solid
颜色White to off-white
常见问题列表
生物活性
Integrin modulator 1 是一种有效和选择性的 α4β1 整联蛋白激动剂，IC50 值为 9.8 nM。Integrin modulator 1 增加了 α4β1 整联蛋白介导的细胞粘附，EC50 值为 12.9 nM。靶点
|
α4β1 9.8 nM (IC 50 ) |
体外研究
Integrin modulator 1 (2-10 μg/mL; 30 min) significantly increases Jurkat E6.1 cell adhesion.
Integrin modulator 1 (1-100 nM; 1 h) strongly and significantly increases ERK1/2 phosphorylation in Jurkat E6.1 cells.
Integrin modulator 1 (1 nM-10 μM; 30 min) significantly increases the binding of HUTS-21 antibody to Jurkat E6.1 cells in a concentration-dependent manner.