202402-01-5
中文名称
GET 73;GET-73;GET73
英文名称
GET-73
CAS
202402-01-5
分子式
C13H16F3NO2
分子量
275.27
MOL 文件
202402-01-5.mol
更新日期
2024/08/02 14:00:33
202402-01-5 结构式
物理化学性质
沸点394.7±42.0 °C(Predicted)
密度1.175±0.06 g/cm3(Predicted)
储存条件Sealed in dry,Room Temperature
溶解度DMSO : 100 mg/mL (363.28 mM; Need ultrasonic)
酸度系数(pKa)15.11±0.46(Predicted)
形态Solid
颜色White to off-white
常见问题列表
生物活性
GET73 是一种天然神经递质 γ-羟基丁酸 (GHB) 的类似物。GET73 具有抗酒精和抗焦虑的特性。GET73 对谷氨酸在海马的传递有显著的影响。体外研究
GET73 (1 µM, 10 µM; 1 hour) 1 hour before and during chronic ethanol exposure prevents ethanol-induced a reduction of cell viability, an alteration of cytoskeleton, a decrease in extracellular glutamate levels and an increase of reactive oxygen species production.
Cell Viability Assay
| Cell Line: | Rat hippocampal neurons |
| Concentration: | 0.1 µM, 1 µM, 10 µM |
| Incubation Time: | 1 hour |
| Result: | Prevented the ethanol (75 mM, 4 days) -induced MTT reduction. |
体内研究
GET73 (5–50 mg/kg; i.g.) exerts an anxiolytic effect in Sprague-Dawley rats exposed to the elevated plus maze (EPM) test.
| Animal Model: | Male SD rats (200-300 g and 300–350 g) |
| Dosage: | 5 mg/kg, 10 mg/kg, 25 mg/kg, 50 mg/kg |
| Administration: | Oral gavage |
| Result: | Exerted an anxiolytic effect in rats exposed to the elevated plus maze (EPM) test. |