2026635-66-3
中文名称
GNE 5729
英文名称
(1R,2R)-2-(7-CHLORO-2-((5-CHLORO-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL)METHYL)-4-OXO-4H-PYRIDO[1,2-A]PYRIMIDIN-6-YL)CYCLOPROPANE-1-CARBONITRILE
CAS
2026635-66-3
分子式
C17H10Cl2F3N5O
分子量
428.2
MOL 文件
2026635-66-3.mol
2026635-66-3 结构式
基本信息
中文别名
化合物 T15408 英文别名
GNE 5729(1R,2R)-2-(7-CHLORO-2-((5-CHLORO-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL)METHYL)-4-OXO-4H-PYRIDO[1,2-A]PYRIMIDIN-6-YL)CYCLOPROPANE-1-CARBONITRILE
物理化学性质
沸点527.6±60.0 °C(Predicted)
密度1.71±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)0.89±0.70(Predicted)
形态Solid
颜色White to yellow
应用领域
用途一
GNE-5729 is a potent and selective NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile. GNE-5729 had a very selective profile against various off-target ion channels with greater than a 100-fold selectivity over other NMDAR subtypes and greater than a 1000-fold selectivity over AMPAR. The improved pharmacokinetic profile and AMPAR selectivity make GNE-5729 a superior tool compound compare to GNE-0723 for testing the efficacy and safety of GluN2A potentiation.