204592-94-9

中文名称 3-Pyridinecarboxamide, 6-[4-[2-[[(2S)-3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]-2-methylpropyl]phenoxy]-

英文名称 3-Pyridinecarboxamide, 6-[4-[2-[[(2S)-3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]-2-methylpropyl]phenoxy]-

CAS 204592-94-9

分子式 C31H32N4O4

分子量 524.61

MOL 文件 204592-94-9.mol

204592-94-9 结构式

基本信息物理化学性质 3-Pyridinecarboxamide, 6-[4-[2-[[(2S)-3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]-2-methylpropyl]phenoxy]-价格(试剂级) 常见问题列表

基本信息

中文别名

化合物 T15819

英文别名

LY377604
LY-377604,LY377604
3-Pyridinecarboxamide, 6-[4-[2-[[(2S)-3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]-2-methylpropyl]phenoxy]-

物理化学性质

沸点809.4±65.0 °C(Predicted)

密度1.282±0.06 g/cm3(Predicted)

酸度系数(pKa)13.94±0.20(Predicted)

形态Solid

颜色Off-white to light brown

常见问题列表

生物活性

LY377604 是一种人类 β3-肾上腺素受体激动剂，其 EC50 值为 2.4 nM，同时也是 β1 和 β2 肾上腺素能受体的拮抗剂。

靶点

EC50: 2.4 nM (human β ₃ -adrenergic receptor) β ₁ -adrenergic receptor, β ₂ -adrenergic receptor

体外研究

LY377604 is a human β ₃ -adrenergic receptor agonist with an EC ₅₀ of 2.4 nM and also a β ₁ - and β ₂ -adrenergic receptor antagonist. LY377604 causes a maximal increase in cyclic adenosine monophosphate (cAMP) levels, but does not stimulate cAMP accumulation in CHO cells transfected with either the human β ₁ adrenergic receptor or the human β ₂ adrenergic receptor.

体内研究

Administration of LY377604 to male Long-Evans rats fed a caloric dense diet results in stimulation of lipid utilization. This is observed as a decrease in respiratory quotient and persists for about 4 h before returning to that measured from vehicle-treated rats.