204992-09-6
中文名称
NETAMIFTIDE
英文名称
NETAMIFTIDE
CAS
204992-09-6
分子式
C37H45F7N10O10
分子量
808.79
MOL 文件
204992-09-6.mol
204992-09-6 结构式
基本信息
中文别名
NEMIFITIDE DITFA 英文别名
NETAMIFTIDEINN 00835 diTFA
Nemifitide diTFA
Bis(trifluoroacetate)
Netamiftide ditriflutate
(2S)-N-[(1S)-1-[[(1S)-1-[[(2S)-2-amino-3-(4-fluorophenyl)propanoyl]carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoylmethylcarbamoyl]-4-(diaminomethylideneamino)butyl]-4-hydroxy-pyrrolidine-2-carboxamide
NETAMIFTIDE价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-105077A | NETAMIFTIDE Nemifitide diTFA | 204992-09-6 | 5mg | 2500元 |
| 2024/04/30 | HY-105077A | NETAMIFTIDE Nemifitide diTFA | 204992-09-6 | 10mg | 4500元 |
| 2024/04/30 | HY-105077A | NETAMIFTIDE Nemifitide diTFA | 204992-09-6 | 10mM * 1mLin Water | 4570元 |
常见问题列表
生物活性
Nemifitide diTFA (INN 00835 diTFA) 是一种合成的五肽抗抑郁药，具有迅速起效的潜力。Nemifitide diTFA 是黑色素细胞抑制因子 (MIF) 的肽类似物。Nemifitide diTFA 可以透过血脑屏障。体外研究
Nemifitide diTFA (INN 00835 diTFA) and its active metabolite (M1) bind at micromolar concentrations to several receptors including the 5-HT 2A , 5-HT 2C , melanocortin MC4, MC5 and bombesin.
体内研究
Nemifitide diTFA (INN 00835 diTFA; 0.3 mg/kg; IP; daily; for 14 days) significantly increases swimming in the FSL rats after just 5 days of treatment and has long-lasting effect.
Nemifitide diTFA (0.0125-15.0 mg/kg) significantly increases swimming in the FSL rats at both low (0.025-0.3 mg/kg) and high (3.0-15.0 mg/kg) doses but not at intermediate (0.4-2.4 mg/kg) doses.
| Animal Model: | Male Flinders Sensitive Line (FSL) rat weighing 280-320 g |
| Dosage: | 0.3 mg/kg |
| Administration: | IP; daily; for 14 days |
| Result: | Significantly increased swimming in the FSL rats after just 5 days of treatment and had long-lasting effect. |