2055047-18-0
中文名称
Azido-PEG3-Val-Cit-PAB-PNP
英文名称
Azido-PEG3-Val-Cit-PAB-PNP
CAS
2055047-18-0
分子式
C34H47N9O12
分子量
773.8
MOL 文件
2055047-18-0.mol
更新日期
2023/06/09 11:23:42
2055047-18-0 结构式
常见问题列表
生物活性
Azido-PEG3-Val-Cit-PAB-PNP 是一种可降解 (cleavable) 的含 3 个单元 PEG 的 ADC linker,可用于合成抗体偶联药物 (ADC)。Azido-PEG3-Val-Cit-PAB-PNP 还是一种 PROTAC linker,属于 PEG 类,可用于合成 PROTAC 分子。靶点
PEGs
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Cleavable
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体外研究
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.