205640-90-0
中文名称
促食素A
英文名称
Orexin A (bovine, human, mouse, rat)
CAS
205640-90-0
分子式
C152H247N47O44S4
分子量
3565.14
MOL 文件
205640-90-0.mol
更新日期
2024/12/18 11:18:12
205640-90-0 结构式
基本信息
中文别名
下视丘分泌素PYR-PRO-LEU-PRO-ASP-CYS-CYS-ARG-GLN-LYS-THR-CYS-SER-CYS-ARG-LEU-TYR-GLU-LEU-LEU-HIS-GLY-ALA-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-LEU-NH2(DISULFIDE BRIDGE: CYS6-CYS12, CYS7-CYS14)
英文别名
OREXIN AHYPOCRETIN
Hypocretin 1
OREXIN A (HUMAN, RAT, MOUSE)
M.W. 3561.12 C152H243N47O44S4
OREXINS OREXIN A HUMAN, RAT, MOUSE
OREXIN A, BOVINE, HUMAN, MOUSE, RAT
OREXIN A (HUMAN, BOVINE, MOUSE, RAT)
OREXIN A (HUMAN, BOVINE, RAT, MOUSE)
OREXIN-A (HUMAN) (RAT, MOUSE, BOVINE)
所属类别
生物化工：多肽物理化学性质
密度1.53±0.1 g/cm3(Predicted)
储存条件-15°C
溶解度Soluble to 1 mg/ml in sterile
形态结晶固体
颜色White to off-white
水溶解性Soluble in water at 1mg/ml
序列Glp-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-IIE-Leu-Thr-Leu-NH2 (Disulfide bridge: Cys6-Cys12, Cys7-Cys14)
促食素A价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/11/08 | HY-106224 | 促食素A Orexin A (human, rat, mouse) | 205640-90-0 | 1mg | 4400元 |
| 2023/03/20 | HY-106224 | 促食素A Orexin A (human, rat, mouse) | 205640-90-0 | 5mg | 18000元 |
常见问题列表
生物活性
Orexin A human, rat, mouse 是一种 33 氨基酸兴奋性神经肽，参与多种中枢和外周过程。Orexin A human, rat, mouse 是一种特异性、高亲和力的 G 蛋白偶联受体 OX1R 激动剂，在调节摄食行为中起重要作用。Orexin A human, rat, mouse 是一种有效的抗伤害和抗痛觉过敏的药物。体外研究
Orexin A human, rat, mouse has high affinity for OX1R, with 38 nM IC 50 and 34 nM EC 50 values in the the [Ca 2﹢ ]i transient assay.
体内研究
Orexin A human, rat, mouse (3-30 mg/kg; i.v.; 5 min pre-test) significantly increases the latency to response at 10 and 30 mg/kg i.v. when given 5 min pre-test from 24.8±2.0 s in vehicle-treated mice to 35.0±3.7 s and 45.7±4.5 s, respectively.
Orexin A human, rat, mouse (3, 10 and 30 mg/kg; i.v.) was given immediately before phenylp-quinone (PPQ) and increases the latency to the first PPQ-induced constriction from 357.4±35.2 s in vehicle-treated mice to 500.3±31.2 s at 10 mg/kg and 594.5±5.5 s at 30 mg/kg.
| Animal Model: | Female mice (mouse carrageenan-induced thermal hyperalgesia test) |
| Dosage: | 3, 10 and 30 mg/kg |
| Administration: | i.v.; 5 min pre-test |
| Result: | Significantly increased the latency to response at 10 and 30 mg/kg. |