2058116-52-0
2058116-52-0 结构式
基本信息
中文别名
化合物 T28008 英文别名
MDVN1003MDVN1003
MDVN-1003
MDVN 1003
1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-(5-amino-2,3-dihydro-1H-inden-2-yl)-3-(8-fluoro-3,4-dihydro-2H-1,4-benzoxazin-6-yl)-, (+)-
应用领域
用途一
MDVN1003 is a potent inhibitor of BTK amd PI3K delta. MDVN1003 inhibits Bruton's tyrosine kinase (BTK) and phosphatidylinositol-3-kinase delta (PI3Kδ), two proteins regulated by the B cell receptor (BCR) that drive the growth of many NHLs. MDVN1003 induces cell death in a B cell lymphoma cell line but not in an irrelevant erythroblast cell line.