206645-99-0

中文名称 COMPSTATIN

英文名称 Compstatin

CAS 206645-99-0

分子式 C66H99N23O17S2

分子量 1550.77

MOL 文件 206645-99-0.mol

更新日期 2024/07/11 10:41:48

206645-99-0 结构式

基本信息物理化学性质 COMPSTATIN价格(试剂级) 常见问题列表

基本信息

中文别名

坎普他汀
坎普他汀, >98%
COMPSTATIN游离态

英文别名

Compstatin
Compstatin,ICVVQDWGHHRCT, >98%
H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2
H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2, (Disulfide bond)
Compstatin trifluoroacetate salt H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2 trifluoroacetate salt (Disulfide bond)
L-Threoninamide, L-isoleucyl-L-cysteinyl-L-valyl-L-valyl-L-glutaminyl-L-α-aspartyl-L-tryptophylglycyl-L-histidyl-L-histidyl-L-arginyl-L-cysteinyl-, cyclic (2→12)-disulfide

物理化学性质

密度1.56±0.1 g/cm3(Predicted)

储存条件Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

酸度系数(pKa)4.00±0.10(Predicted)

形态Solid

颜色White to off-white

水溶解性Soluble to 2 mg/ml in sterile water

序列H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2(Disulfide bridge: Cys2-Cys11)

COMPSTATIN价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/04/30	HY-P1036	COMPSTATIN Compstatin	206645-99-0	500μg	650元
2024/04/30	HY-P1036	COMPSTATIN Compstatin	206645-99-0	1mg	900元
2024/04/30	HY-P1036	COMPSTATIN Compstatin	206645-99-0	5mg	1800元

常见问题列表

生物活性

Compstatin 是一个 13 残基环肽，是补体系统 C3 的有效抑制剂，具有物种特异性。Compstatin 结合到狒狒的 C3，并对狒狒血液中的蛋白水解裂解具有抗性（类似人类）。Compstatin 只抑制灵长类补体系统的激活。Compstatin 对补体经典途径和旁路途径的 IC50 值分别为 63 μM 和 12 μM。

体外研究

Compstatin exhibits an in vitro half-life in human blood of about2 hr.
In solution, compstatin forms a β-turn at residues Gln-5–Gly-8 with the disulfide bridge Cys-2–Cys12, residues Ile-1–Val-4, and Thr-13, forming a hydrophobic cluster.

体内研究

Compstatin (21 mg/kg) produces complete inhibition when given as a combination of bolus injection and infusion. Compstatin completely inhibits in vivo heparin/protamine-induced complement activation without adverse effects on heart rate or systemic arterial, central venous, and pulmonary arterial pressures.
Compstatin is stable in baboon plasma for more than 24 h.
Pig xenografts survival is significantly longer in the Compstatin perfused group than in the control group.

Animal Model:	Juvenile baboons ( P. Anubis ) weighing 10.5-28.8 kg.
Dosage:	50, 25 mg/kg 60 min after heparin and 2 min before protamine.
Administration:	A bolus injection.
Result:	Completely inhibited complement activation induced by heparin–protamine complexes.