2070015-13-1
中文名称
ML241 (hydrochloride)
英文名称
ML241 (hydrochloride)
CAS
2070015-13-1
分子式
C23H25ClN4O
分子量
408.93
MOL 文件
2070015-13-1.mol
更新日期
2023/03/20 15:41:27
2070015-13-1 结构式
ML241 (hydrochloride)价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-19797A | ML241 (hydrochloride) ML241 hydrochloride | 2070015-13-1 | 5mg | 600元 |
| 2024/04/30 | HY-19797A | ML241 (hydrochloride) ML241 hydrochloride | 2070015-13-1 | 10mg | 960元 |
| 2024/04/30 | HY-19797A | ML241 (hydrochloride) ML241 hydrochloride | 2070015-13-1 | 25mg | 1950元 |
常见问题列表
生物活性
ML241 hydrochloride 是一种 p97 的有效选择性抑制剂，对 p97 ATPase 和 UbG76V–GFP 的IC50值分别为0.11 μM和3.5 μM。靶点
| Target | Value |
|
p97 ATPase
(Cell-free assay) | 0.11 μM |
|
Ub
(Cell-free assay) | 3.5 μM |
体外研究
ML241 hydrochloride is a potent p97 inhibitor, inhibiting p97 ATPase with IC 50 values of 100 nM. ML241 inhibits p97 competitively with respect to ATP with a K i values of 0.35 μM. ML241 (20 μM) shows no obvious inhibition of the appr 170 kinases tested. ML241 stabilizes Ub G76V -GFP with IC 50 of 3.5 μM. ML241 is cytotoxic to HCT15 and SW403 cells, with GI 50 s of 53 and 33 μM after treatment for 24 h, and 13 and 12 μM after treatment for 72 h, respectively.