常见问题列表
生物活性
NVP-DPP728 dihydrochloride 是一种高效、选择性的二肽基肽酶 IV (DPP-IV) 抑制剂，其 Ki 为 11 nM。NVP-DPP728 dihydrochloride 可用于糖尿病的研究。靶点
Ki: 11 nM (DPP-IV)
体外研究
NVPDPP728 inhibits human and rat plasma DPP-IV (IC
50
s: 5-10 nM) with >15 000-fold selectivity relative to DPP-II and a range of proline-cleaving proteases.
体内研究
NVP-DPP728 (3.72 mg/kg; p.o.) inhibits DPP-IV and improves insulin secretion and glucose tolerance, probably through augmentation of the effects of endogenous GLP-1.
| Animal Model: | Obese (fa/fa) and lean (FA/?) Zucker rats |
| Dosage: | 3.72 mg/kg |
| Administration: | Oral administration |
| Result: | Led to inhibition of plasma DPP-IV activity. |