207572-68-7
中文名称
RILMENIDINE HEMIFUMARATE SALT
英文名称
RILMENIDINE HEMIFUMARATE SALT
CAS
207572-68-7
分子式
2C10H16N2O.C4H4O4
分子量
476.57
MOL 文件
207572-68-7.mol
207572-68-7 结构式
基本信息
中文别名
化合物 T21911 英文别名
LZFATBMLSYHRTC-WXXKFALUSA-NRILMENIDINE HEMIFUMARATE SALT
n-(dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine hemifumarate salt
Oxaminozoline hemifumarate salt, Rilmenidene hemifumarate salt, N-(Dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine hemifumarate salt
常见问题列表
生物活性
Rilmenidine hemifumarate 是一种新型的抗高血压药物和口服活性选择性 I1 咪唑啉受体 (I1 imidazoline receptor) 激动剂。Rilmenidine hemifumarate 也是一种 α2 肾上腺素受体激动剂。Rilmenidine phosphate 诱导自噬 (autophagy)。Rilmenidine hemifumarate 可通过减少交感神经过度活跃而发挥中枢作用，并通过抑制 Na+/H+ 反向转运而在肾脏中发挥作用。Rilmenidine hemifumarate可调节白血病细胞增殖，刺激促凋亡蛋白 Bax，从而诱导人白血病 K562 细胞线粒体通路的紊乱和凋亡。体外研究
Rilmenidine provides antihypertensive efficacy comparable with that of diuretics, beta-blockers, calcium channel blockers, and angiotensin-converting enzyme (ACE) inhibitors.
Rilmenidine (25-100 μM; 24 hours) inhibits K562 cell proliferation.
Cell Viability Assay
| Cell Line: | K562 cells |
| Concentration: | 25, 50, 100 μM |
| Incubation Time: | 24 hours |
| Result: | Dose-dependently inhibited K562 colony formation. |
体内研究
Rilmenidine-treated N171-82Q mice (i.p.; 4-times a week) displays significant improved forelimb grip strength and all limbs grip strength from 12 to 22 weeks of age.
Rilmenidine decreases levels of mutant huntingtin.