208518-52-9
208518-52-9 结构式
基本信息
中文别名
埃博霉素F 英文别名
CS-1032epothilone F
epothilone F USP/EP/BP
Ixabepilone Impurity 8 (Epothilone F)
(1S,3S(E),7S,10R,11S,12S,16R)-7,11-dihydroxy-3-[2-(2-hydroxymethyl-thiazol-4-yl)-1-methyl-vinyl]-8,8,10,12,16-pentamethyl-4,17-dioxa-bicyclo[14.1.0]heptadecane-5,9-dione
4,17-Dioxabicyclo[14.1.0]heptadecane-5,9-dione, 7,11-dihydroxy-3-[(1E)-2-[2-(hydroxymethyl)-4-thiazolyl]-1-methylethenyl]-8,8,10,12,16-pentamethyl-, (1S,3S,7S,10R,11S,12S,16R)-
所属类别
原料药：天然来源类抗肿瘤药应用领域
用途一
Epothilone F is a related compound of Epothilones, which are a novel class of antineoplastic agents with antitubulin activity. In addition, Epothilones utilize a similar mechanism of action to that of taxanes and are less susceptible to multidrug resistance caused by P-glycoprotein. Studies showed that Epothilones exhibit antitumor activity against human cancer cells that are taxane-resistant.