2086689-94-1

中文名称化合物 T28293

英文名称 5,6,7a,11-Tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one, 2-fluoro-5,8,9,10,10a,11-hexahydro-10a-methyl-, (10aR)-, (2Z)-2-butenedioate (2:3)

CAS 2086689-94-1

分子式 C20H19FN4O5

分子量 414.39

MOL 文件 2086689-94-1.mol

2086689-94-1 结构式

基本信息应用领域

基本信息

中文别名

化合物 T28293

英文别名

BGB-29 maleat 0
Pamiparib maleate
5,6,7a,11-Tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one, 2-fluoro-5,8,9,10,10a,11-hexahydro-10a-methyl-, (10aR)-, (2Z)-2-butenedioate (2:3)

应用领域

用途一

Pamiparib, also known as BGB-290, is a highly potent and selective PARP inhibitor with favorable drug metabolism and pharmacokinetic properties. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of single-strand DNA breaks via the base-excision repair (BER) pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability, and eventually leads to apoptosis. BGB-290 may both potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo- and radioresistance.