2089205-64-9
中文名称
2-[2-[2-[2][4-[(5-苯并噻唑基氨基)-6-[(1,1-二甲基乙基)磺酰基]-7-喹啉基]氧基]乙氧基]甲氧基]乙基]乙氧基]-N-[2-(2,6-二氧代-3-哌啶基)-2,3-二氢-1-氧代-1H-异吲哚-4-基]-乙酰胺
英文名称
Acetamide, 2-[2-[2-[2-[2-[[4-(5-benzothiazolylamino)-6-[(1,1-dimethylethyl)sulfonyl]-7-quinolinyl]oxy]ethoxy]ethoxy]ethoxy]ethoxy]-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]-
CAS
2089205-64-9
分子式
C43H48N6O11S2
分子量
889
MOL 文件
2089205-64-9.mol
2089205-64-9 结构式
基本信息
中文别名
2-[2-[2-[2][4-[(5-苯并噻唑基氨基)-6-[(1,1-二甲基乙基)磺酰基]-7-喹啉基]氧基]乙氧基]甲氧基]乙基]乙氧基]-N-[2-(2,6-二氧代-3-哌啶基)-2,3-二氢-1-氧代-1H-异吲哚-4-基]-乙酰胺 英文别名
PROTAC RIPK degrader-6Acetamide, 2-[2-[2-[2-[2-[[4-(5-benzothiazolylamino)-6-[(1,1-dimethylethyl)sulfonyl]-7-quinolinyl]oxy]ethoxy]ethoxy]ethoxy]ethoxy]-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]-
物理化学性质
沸点1111.1±65.0 °C(Predicted)
密度1.398±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO: 100 mg/mL (112.49 mM)
酸度系数(pKa)10.68±0.40(Predicted)
形态Solid
颜色Light yellow to yellow
常见问题列表
生物活性
PROTAC RIPK degrader-6 (example 1) 是一种 PROTAC 类的有效 RIPK 降解剂。靶点
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Cereblon
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体外研究
PROTACs is useful for the targeted degradation of proteins and other polypeptides which on the one end binds to the cereblon and on the other end to the target protein (RIP2 kinase). By bringing the target protein in close proximity to the E3-Ligase, these compounds form a ternary complex leading to polyubiquitination of the target protein inducing its degradation.