2089647-47-0
中文名称
化合物SGN-2FF
英文名称
SGN-2FF
CAS
2089647-47-0
分子式
C6H11FO4
分子量
166.15
MOL 文件
2089647-47-0.mol
更新日期
2023/03/20 15:41:27
2089647-47-0 结构式
物理化学性质
沸点323.7±42.0 °C(Predicted)
密度1.42±0.1 g/cm3(Predicted)
储存条件Store at -20°C,protect from light
酸度系数(pKa)11?+-.0.70(Predicted)
形态Solid
颜色White to off-white
水溶解性Water : 36.67 mg/mL (220.70 mM)
化合物SGN-2FF价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/08/19 | HY-107366 | 化合物SGN-2FF SGN-2FF | 2089647-47-0 | 5mg | 1500元 |
| 2024/08/19 | HY-107366 | 化合物SGN-2FF SGN-2FF | 2089647-47-0 | 10mg | 2400元 |
| 2024/08/19 | HY-107366 | 化合物SGN-2FF SGN-2FF | 2089647-47-0 | 10mM * 1mLin Water | 3133元 |
常见问题列表
生物活性
SGN-2FF 是一种有效的，具有口服活性的岩藻糖基化抑制剂，抑制岩藻糖基转移酶 (fucosyltransferase) 的活性，具有抗肿瘤活性。靶点
Fucosyltransferase
体外研究
SGN-2FF (2-Fluorofucose) is an inhibitor of fucosylation, inhibits cellular fucosylation by depleting the fucosylation substrate GDP-fucose, and by direct inhibition of fucosyltransferases, and leads to the production of afucosylated glycoproteins including antibodies. SGN-2FF activates human T cells in an antigen-dependent manner.
体内研究
SGN-2FF exhibits antitumor activity in multiple mouse tumor models, showing substantial tumor growth delay. SGN-2FF elevates the protective effect of a lymphoma vaccine in a syngeneic mouse model.