2097887-21-1
英文名称
MM-589 TFA salt
CAS
2097887-21-1
物理化学性质
储存条件-20°C, away from moisture
溶解度DMSO : 25 mg/mL (36.40 mM; ultrasonic and warming and heat to 60°C)
肽价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/08/19 | HY-100869A | 肽 MM-589 TFA | 2097887-21-1 | 1mg | 9980元 |
| 2023/03/20 | HY-100869A | 肽 MM-589 TFA | 2097887-21-1 | 2 mg | 18000元 |
常见问题列表
生物活性
MM-589 TFA 是 WD 重复结构域 5 (WDR5) 和混合谱系白血病 (MLL) 蛋白-蛋白相互作用的有效抑制剂。MM-MM-589 TFA 结合 WDR5 的 IC50 为 0.90 nM。抑制 MLL H3K4 甲基转移酶活性的 IC50 为 12.7 nM。靶点
IC50: 0.90 nM (WDR5), 12.7 nM (HMT)
Ki: <1 nM (WDR5)
体外研究
MM-589 (0.01-10 µM, 4 days or 7 days) potently and selectively inhibits cell growth in human leukemia cell lines harboring MLL translocations.
Cell Viability Assay
| Cell Line: | MV4-11 and MOLM-13 cells |
| Concentration: | 0.01, 0.1, 1, 10 μM |
| Incubation Time: | 4 days or 7 days |
| Result: | Potently inhibited MV4-11 and MOLM-13 cell growth with IC 50 s of 0.25 and 0.21 μM, respectively. Had much weaker activity in the inhibition of cell growth of the HL-60 cell line with an IC 50 of 8.6 μM. |