2109805-87-8
中文名称
3-羟基-1-(4-甲氧基苯基)喹唑啉-2,4(1H,3H)-二酮
英文名称
FEN1 Inhibitor C3
CAS
2109805-87-8
分子式
C15H12N2O4
分子量
284.27
MOL 文件
2109805-87-8.mol
2109805-87-8 结构式
基本信息
中文别名
化合物 T91473-羟基-1-(4-甲氧基苯基)喹唑啉-2,4(1H,3H)-二酮
英文别名
FEN1-IN-3FEN1 Inhibitor C3
3-Hydroxy-1-(4-methoxyphenyl)quinazoline-2,4(1H,3H)-dione
2,4(1H,3H)-Quinazolinedione, 3-hydroxy-1-(4-methoxyphenyl)-
物理化学性质
储存条件Inert atmosphere,Store in freezer, under -20°C
溶解度DMSO: 250 mg/mL (879.45 mM)
形态Solid
颜色Light yellow to yellow
3-羟基-1-(4-甲氧基苯基)喹唑啉-2,4(1H,3H)-二酮价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-136484 | 3-羟基-1-(4-甲氧基苯基)喹唑啉-2,4(1H,3H)-二酮 FEN1-IN-3 | 2109805-87-8 | 5mg | 790元 |
| 2024/04/30 | HY-136484 | 3-羟基-1-(4-甲氧基苯基)喹唑啉-2,4(1H,3H)-二酮 FEN1-IN-3 | 2109805-87-8 | 10mM * 1mLin DMSO | 869元 |
| 2024/04/30 | HY-136484 | 3-羟基-1-(4-甲氧基苯基)喹唑啉-2,4(1H,3H)-二酮 FEN1-IN-3 | 2109805-87-8 | 10mg | 1200元 |
常见问题列表
生物活性
FEN1-IN-3 (Compound 4) 是一种人类皮瓣内切核酸酶-1 (hFEN1) 抑制剂。FEN1-IN-3 可使 hFEN1 稳定化，EC50 为 6.8 μM。体外研究
FEN1 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a , both frequently mutated in colorectal cancers. FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of Methyl methanesulfonate-induced alkylation damage, and its knockdown or inhibition increases sensitivity to Temozolomide in glioblastoma and colorectal cancer cell lines.