2110444-63-6
2110444-63-6 结构式
基本信息
英文别名
Boc-Gly-PEG3-endo-BCN9,12,15-Trioxa-2,5,19-triazaeicosanedioic acid, 4-oxo-, 20-(bicyclo[6.1.0]non-4-yn-9-ylmethyl) 1-(1,1-dimethylethyl) ester
常见问题列表
生物活性
Boc-gly-PEG3-endo-BCN 是一种 PROTAC linker，属于 PEG 类。可用于合成PROTAC分子。Boc-gly-PEG3-endo-BCN 也是一种可降解 (cleavable) 的含 2 个单元 PEG 的 ADC linker，可用于合成抗体偶联药物 (ADC)。靶点
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PEGs
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Alkyl/ether
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Cleavable
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体外研究
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.