21291-40-7

IC50: precursor to glucosepane

Fructosyl-lysine (5 mM; 0.5 hours) catalyzes the ATP-dependent conversion of [ ¹⁴ C]fructoselysine to anionic products suggesting the existence of a fructoselysine-kinase activity in E .coli extracts.Fructosyl-lysine (100 μM; 1 hour) contains a carbohydrate moiety and appears to be phosphorylated, it can be converted to glucose 6-phosphate in bacterial extracts in E .coli extracts.Fructosyl-lysine (25 mM; 25 hours) lets E. coli growth at a rate of about one-third of that observed with glucose as a carbon source. Lysine itself does not support growth in the absence of other carbon source and does not affect the growth observed with glucose.

Fructosyl-lysine and AGE residues is increased markedly in glomeruli, retina, sciatic nerve, and plasma protein in diabetic rats.