2136270-20-5

中文名称 SPOP-IN-6b

英文名称 SPOP-IN-6b

CAS 2136270-20-5

分子式 C28H32N6O3

分子量 500.59

MOL 文件 2136270-20-5.mol

更新日期 2023/03/20 15:41:25

2136270-20-5 结构式

基本信息物理化学性质图谱信息常见问题列表

基本信息

中文别名

化合物 T16922
化合物SPOP-IN-6B

英文别名

SPOP-IN-6b
2H-Dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide, 1,5-dihydro-2-imino-10-methyl-N-[3-(4-morpholinyl)propyl]-5-oxo-1-(2-phenylethyl)-

物理化学性质

密度1.32±0.1 g/cm3(Predicted)

储存条件-20°C储存

溶解度DMSO: 10 mg/mL (19.98 mM)

酸度系数(pKa)11.90±0.20(Predicted)

形态Solid

颜色Light yellow to yellow

图谱信息

SPOP-IN-6b(2136270-20-5)核磁图(¹HNMR)

常见问题列表

生物活性

SPOP-IN-6b 是一种 SPOP 抑制剂，来自专利 CN 107141287，化合物 SPOP-B-88。

靶点

SPOP

体外研究

SPOP-IN-6b a SPOP inhibitor with an IC ₅₀ of 3.58 μM in cell assay.
SPOP-IN-6b (0.1-3.0 μM; 10 hours) can suppress SPOP activity, and then increase suppression cancer substrate protein PTEN and DUSP7 content.
SPOP-IN-6b suppresses intracellular SPOP acted on substrate PTEN ubiquitination.

Cell Viability Assay

Cell Line:	A498 cells
Concentration:	0.1 μM, 0.3 μM, 1.0 μM, 3.0 μM
Incubation Time:	10 hours
Result:	Suppress SPOP activity, and then increase suppression cancer substrate protein PTEN and DUSP7 content.

体内研究

SPOP-IN-6b (40-80 mg/kg; i.p.; daily; for 25 days) can slow down the growth of tumour by suppressing SPOP.

Animal Model:	Nude mice
Dosage:	40 mg/kg, 60 mg/kg, 80 mg/kg
Administration:	Intraperitoneal injection; daily; for 25 days
Result:	Slowed down the growth of tumour by suppressing SPOP.