2137047-43-7
2137047-43-7 结构式
基本信息
化合物VU6005649
VU6005649
VU-6005649
VU 6005649
VU6005649
VU-6005649
VU 6005649
Pyrazolo[1,5-a]pyrimidine, 3-(2,3-difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)-
物理化学性质
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/11/08 | HY-107982 | CS-2729 VU6005649 | 2137047-43-7 | 5mg | 700元 |
| 2024/11/08 | HY-107982 | CS-2729 VU6005649 | 2137047-43-7 | 10mM * 1mLin DMSO | 770元 |
| 2024/11/08 | HY-107982 | CS-2729 VU6005649 | 2137047-43-7 | 10mg | 1100元 |
常见问题列表
|
mGlu7 Receptor 0.65 μM (EC 50 ) |
mGlu8 Receptor 2.6 μM (EC 50 ) |
VU6005649 is a CNS penetrant mGlu 7/8 receptor agonist with EC 50 s of 0.65 μM and 2.6 μM for mGlu 7 receptor and mGlu 8 receptor, respectively. VU6005649 displays a terminal K p of 2.43 with total brain levels ~9× above the mGlu 7 positive allosteric modulator (PAM) in vitro EC 50 .
When VU6005649 (compound 9f) is dosed at 30 mg/kg IP in 10% Tween 80/H 2 O (0.75 mg/kg. s.c. amphetamine), no efficacy is observed in this assay. VU6005649 shows modest but significant pro-cognitive effects on associative learning in wild-type mice and the first example of efficacy of an mGlu 7/8 positive allosteric modulator (PAM) in this model.