216691-95-1
中文名称
216691-95-1
英文名称
7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthylmethyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one
CAS
216691-95-1
分子式
C27H21ClN2O2
分子量
440.92
MOL 文件
216691-95-1.mol
216691-95-1 结构式
基本信息
中文别名
化合物 T14846 英文别名
BZ48Bz-423
Bz-423 >=98% (HPLC)
7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthylmethyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one
7-Chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthalenylmethyl)-2H-1,4-benzodiazepin-2-one
2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-Methyl-3-(2-naphthalenylMethyl)-
物理化学性质
沸点697.2±55.0 °C(Predicted)
密度1.28±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO : ≥ 125 mg/mL (283.50 mM)
酸度系数(pKa)9.05±0.30(Predicted)
216691-95-1价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-13108 | 216691-95-1 Bz 423 | 216691-95-1 | 5mg | 950元 |
| 2024/04/30 | HY-13108 | 216691-95-1 Bz 423 | 216691-95-1 | 10mM * 1mLin DMSO | 1050元 |
| 2024/04/30 | HY-13108 | 216691-95-1 Bz 423 | 216691-95-1 | 10mg | 1550元 |
常见问题列表
生物活性
Bz 423 是一种促凋亡的1,4-苯并二氮平类化合物，能够活化 Bax 和 Bak，能用于红斑狼疮等自身免疫病的研究。靶点
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Bax
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Bak
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体外研究
Bz-423 induces a larger superoxide response in Ramos cells, and causes rapid death of Ramos B cells. Bz-423 activates Bax and Bak, but does not activate ASK1/JNK in Ramos cells. In Ramos cells Bz-423-induced superoxide leads to Bax and Bak activation via changes in Mcl-1 expression and functional activation of BH3-only proteins. Bz-423 rapidly increases superoxide levels in MEFs within 1 h and the magnitude of the increase is concentration-dependent. Bz-423-induced apoptosis dependents upon superoxide.