218136-59-5
中文名称
ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈
英文名称
α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile
CAS
218136-59-5
分子式
C27H29N5
分子量
423.55
MOL 文件
218136-59-5.mol
更新日期
2023/03/20 15:41:23
218136-59-5 结构式
基本信息
中文别名
ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈 英文别名
CS-117SC 26196
PF-o6341724
SC26196
SC 26196
SC 26196 - PF 06341724
α,α-Diphenyl-4-[(3-pyridinylMethylene)aMino]-1-piperazine
a,a-diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile
α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile
1-Piperazinepentanenitrile, α,α-diphenyl-4-[(3-pyridinylmethylene)amino]-
alpha,alpha-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile
所属类别
生物化工：抑制剂
常见问题列表
应用
SC-26196 是一种有效的，具有口服活性的 Delta6 去饱和酶 (D6D, FADS2) 抑制剂 (在大鼠肝微粒体中，IC50=0.2 µM)。具有抗炎活性。生物活性
SC-26196 是一种有效的，具有口服活性的 Delta6 去饱和酶 (D6D, FADS2) 抑制剂 (在大鼠肝微粒体中，IC50=0.2 µM)。具有抗炎活性。靶点
IC50: 0.2 µM (Delta6 desaturase in a rat liver microsomal assay)
体外研究
SC-26196 (200 nM) inhibits proliferation of peripheral blood mononuclear cells (PBMCs), but Not Jurkat Cells.
Cell Proliferation Assay
| Cell Line: | PBMCs and Jurkat cells |
| Concentration: | 200 nM |
| Incubation Time: | 96 hours for PBMCs; 144 hours for Jurkat cells |
| Result: |
Treatment of PBMCs significantly decreased the proportion of cells that underwent division, the division index and proliferation index.
Did not alter cell proliferation significantly in Jurkat cells. |
体内研究
SC-26196 ( included in the diet at 0, 0.07, 0.21, or 0.7 mg/kg diet to achieve dosages of 0, 10, 30, and 100 mg/kg per day) causes a decrease in the calculated Δ6-desaturase index in both adipose tissue and liver. Feeding 100 mg SC-26196 per kg BW per day inhibits the Δ6-desaturase enzyme.
| Animal Model: | Male mice (12- or 15-week-old) |
| Dosage: | 0, 10, 30, and 100 mg/kg per day |
| Administration: | Included in the diet at 0, 0.07, 0.21, or 0.7mg/kg diet to achieve dosages of 0, 10, 30, and 100mg/kg per day. |
| Result: | Caused a decrease in the calculated Δ6-desaturase index in both adipose tissue and liver. |