21853-11-2
中文名称
5α-Pregnane-3β,6α-diol-20-one
英文名称
5α-Pregnane-3β,6α-diol-20-one
CAS
21853-11-2
分子式
C21H34O3
分子量
334.49
MOL 文件
21853-11-2.mol
更新日期
2024/08/21 10:13:10
21853-11-2 结构式
物理化学性质
熔点202-203 °C
沸点469.7±30.0 °C(Predicted)
密度1.117±0.06 g/cm3(Predicted)
酸度系数(pKa)14.72±0.70(Predicted)
形态Solid
颜色White to off-white
常见问题列表
生物活性
5α-Pregnane-3β,6α-diol-20-one 是一种促进有丝分裂的 progesterone 代谢物，可于血清不足时雄性激素反应的前列腺素癌细胞中产生。体外研究
Progesterone is converted to 5α-pregnane-3β,6α-diol-20-one in human fibroblasts. Pregnenolone and progesterone are avidly metabolized to 5α-pregnan-3β,6α-diol-20-one in the C4.2 cell line, with nearly complete conversions at 24 h and 18 h, respectively. Preferential 5α-pregnan-3β,6α-diol-20-one formation from early steroid precursors is independent of CYP17A1 but rather relies on 3β-HSD activity.