220334-14-5
中文名称
Volixibat potassium
英文名称
Volixibat potassium
CAS
220334-14-5
更新日期
2024/07/29 15:56:06
分子式
C39H62N10O15
分子量
910.98
MOL 文件
220334-14-5.mol
220334-14-5 结构式
基本信息
中文别名
化合物 T26629单链尿激酶纤溶酶原激活剂多肽
单链尿激酶纤溶酶原激活剂八肽
英文别名
A-6 peptideVolixibat potassium
Angstrom6/A6 Peptide
所属类别
生物化工：多肽物理化学性质
沸点1469.3±65.0 °C(Predicted)
密度1.409±0.06 g/cm3(Predicted)
储存条件-20°C储存
酸度系数(pKa)4.44±0.10(Predicted)
形态Solid
颜色White to off-white
常见问题列表
生物活性
Angstrom6 (A6 Peptide) 是一种来源于单链尿激酶纤溶酶原激活剂 (scuPA) 的8个氨基酸的肽，可干扰 uPA/uPAR 级联反应并消除下游效应。Angstrom6 与 CD44 结合，抑制肿瘤细胞的迁移、侵袭和转移，调节 CD44 介导的细胞信号。体外研究
Angstrom6 is effective at blocking the migration of the OVCAR8, OVCAR3, ES2, IGROV-1, MDA-MB-468, and MDA-MB361 cells with IC
50
s in the range of 10 to 100 nM.
Angstrom6 potentiates the CD44-dependent adhesion of cancer cells to hyaluronic acid and activated CD44-mediated signaling, as evidenced by focal adhesion kinase and MAP/ERK kinase phosphorylation.
体内研究
Angstrom6 (100 mg/kg; s.c. twice daily) reduces the number of lung foci generated by the i.v. injection of B16-F10 melanoma cells by 50%.
| Animal Model: | C57Bl/6 mice (bearing B16-F10 cells) |
| Dosage: | 100 mg/kg |
| Administration: | S.c.; twice a day for 11 days |
| Result: | Reduced the number of lung nodules and reduced the number of lung metastases to 50% of control. |