220757-88-0
中文名称
TCFA15
英文名称
2-Cyclohexen-1-one, 3-(15-hydroxypentadecyl)-2,4,4-trimethyl-
CAS
220757-88-0
分子式
C24H44O2
分子量
364.61
MOL 文件
220757-88-0.mol
220757-88-0 结构式
基本信息
中文别名
化合物 T13917 英文别名
TCFA153-(15-Hydroxypentadecyl)-2,4,4-trimethylcyclohex-2-enone
2-Cyclohexen-1-one, 3-(15-hydroxypentadecyl)-2,4,4-trimethyl-
物理化学性质
沸点478.1±24.0 °C(Predicted)
密度0.910±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO : 130 mg/mL (356.56 mM);Water : < 0.1 mg/mL (insoluble)
酸度系数(pKa)15.20±0.10(Predicted)
形态Oil
颜色Light yellow to yellow
常见问题列表
生物活性
tCFA15 为一种三甲基环己烯长链脂肪醇，侧链含有 15 个碳原子，能够促进神经细胞的分化，具有调控 Notch 信号通路的潜力。靶点
Notch1
体外研究
tCFA15 (10 nM-1 μM) dose-dependently affects the differentiation of neural stem cell-derived neurospheres by promoting neurons at the expense of astrocytes, and such effect is via Notch1. tCFA15 (1 μM) specifically decreases the level of Notch1 mRNA in spheres, and such an effect is also observed in decreases Notch1 expression in neuronal and glial cell cultures. tCFA15 stimulates arginine vasopressin secretion in nerve terminals of the neurohypophysis.