221287-83-8
221287-83-8 结构式
基本信息
中文别名
脱乙酰基葡糖苷酸钠盐脱乙酰基-D4葡糖苷酸
英文别名
Tizoxanide-d4 GlucuronideTIZOXANIDE GLUCURONIDE, SODIUM SALT
2-[[(5-Nitro-2-thiazolyl)aMino]carbonyl]phenyl β-D-Glucopyranosiduronic Acid
2-[[(5-Nitro-2-thiazolyl)amino]carbonyl]phenyl -D-Glucopyranosiduronic Acid Monosodium Salt
常见问题列表
生物活性
Tizoxanide glucuronide-D4 是氘标记的 Tizoxanide glucuronide。Tizoxanide glucuronide 是硝唑奈德 (HY-B0217) 的代谢物 (metabolite)，具有细胞穿透性，可抑制寄生虫 (parasite) C. parvum 的无性和有性发育阶段。靶点
IC50: parasite
体外研究
Tizoxanide glucuronide (1-50 μg/ml; 46 hours) has effects on parasite development of Cryptosporidium parvum in HCT-8 cells. It exhibits MIC 50 values of 2.2 μg/ml; 45.2 μg/ml; 11.7 μg/ml and 2.8 μg/ml in a sexual and sexual stages, sporozoite stage, asexual stages and sexual stages, respectively.