2225940-48-5
中文名称
Pentanoic acid, 5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
英文名称
Pentanoic acid, 5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
CAS
2225940-48-5
分子式
C18H19N3O6
分子量
373.36
MOL 文件
2225940-48-5.mol
2225940-48-5 结构式
基本信息
中文别名
泊马度胺 4'-烷基C4-酸化合物POMALIDOMIDE-C4-COOH
5-[[2-(2,6-二氧基-3-哌啶基)-2,3-二氢-1,3-二氧基-1H-异吲哚-4-基]氨基]戊酸
英文别名
JUN 40485Pomalidomide-C4-COOH
5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)pentanoic acid
Pentanoic acid, 5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
所属类别
生物化工：抑制剂应用领域
用途一
Pomalidomide-C4-acid, also known as Pomalidomide 4'-alkylC4-acid and JUN 40485, is a Pomalidomide-based cereblon ligand with a linker, which is a useful precursor for synthesis of PROTAC degraders. Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to tackle disease-causing proteins that have historically been highly challenging to target with conventional small molecules. PROTAC degraders are usually heterobifunctional small molecules consisting of two ligands joined by a linker: one ligand recruits and binds a protein of interest (POI) while the other recruits and binds an E3 ubiquitin ligase. Simultaneous binding of the POI and ligase by the PROTAC induces ubiquitylation of the POI and its subsequent degradation by the ubiquitin–proteasome system (UPS), after which the PROTAC is recycled to target another copy of the POI.