2226201-97-2
2226201-97-2 结构式
物理化学性质
密度1.265±0.06 g/cm3(Predicted)
储存条件4°C, stored under nitrogen
溶解度DMSO: 100 mg/mL (232.59 mM)
酸度系数(pKa)13.79±0.46(Predicted)
形态Solid
颜色White to off-white
常见问题列表
生物活性
KSC-34 是蛋白质二硫键异构酶 A1 (PDIA1) 的共价修饰剂，是一种有效的 PDIA1 a位点选择性抑制剂，IC50 为 3.5 μM。KSC-34 对 a′ 结构域的选择性为 30 倍。KSC-34 在复杂蛋白质组中对 PDIA 表现出选择性。靶点
IC50: 3.5 μM (a active site of PDIA1), 104.5 μM (a′ active site of PDIA1)
体外研究
KSC-34 is selective for PDIA1 over other members of the PDI family, and other cellular cysteine-containing proteins. KSC-34 contains a (4-phenylbutyl)methylamine diversity element for optimized binding to the active site of the a domain of PDIA1 with a chloroacetamide electrophile for covalent modification of C53 on PDIA1.