2231079-74-4

中文名称 NCT-505

英文名称 NCT-505

CAS 2231079-74-4

分子式 C27H28FN5O3S

分子量 521.61

MOL 文件 2231079-74-4.mol

2231079-74-4 结构式

基本信息物理化学性质应用领域

基本信息

中文别名

化合物NCT-505

英文别名

NCT-505 free base
1-(6-Fluoro-3-(4-(methylsulfonyl)piperazine-1-carbonyl)quinolin-4-yl)-4-phenylpiperidine-4-carbonitrile
4-Piperidinecarbonitrile, 1-[6-fluoro-3-[[4-(methylsulfonyl)-1-piperazinyl]carbonyl]-4-quinolinyl]-4-phenyl-

物理化学性质

储存条件-20°C储存

溶解度溶于二甲基亚砜

形态Solid

颜色White to off-white

应用领域

用途一

NCT-505 is an Orally Bioavailable aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitor with Potent Cellular Activity (IC50 = 7 nM). NCT-505 demonstrated target engagement in a cellular thermal shift assay (CETSA), inhibited the formation of 3D spheroid cultures of OV-90 cancer cells, and potentiated the cytotoxicity of paclitaxel in SKOV-3-TR, a paclitaxel resistant ovarian cancer cell line. NCT-505 also exhibit high specificity over other ALDH isozymes and unrelated dehydrogenases.