22494-47-9

中文名称氯丁扎利

英文名称 clobuzarit

CAS 22494-47-9

分子式 C17H17ClO3

分子量 304.77

MOL 文件 22494-47-9.mol

更新日期 2023/03/17 20:03:06

22494-47-9 结构式

基本信息物理化学性质图谱信息常见问题列表

基本信息

中文别名

氯丁扎利

英文别名

Clozic
ICI-55897
clobuzarit
2-[(4'-Chloro-4-biphenylyl)methoxy]-2-methylpropionic acid
2-[[4'-Chloro(1,1'-biphenyl)-4-yl]methoxy]-2-methylpropionic acid
2-[(4'-Chloro[1,1'-biphenyl]-4-yl)methoxy]-2-methylpropanoic acid
Propanoic acid, 2-[(4'-chloro[1,1'-biphenyl]-4-yl)methoxy]-2-methyl-

物理化学性质

熔点154-155°

储存条件-20°C储存

溶解度溶于二甲基亚砜

图谱信息

氯丁扎利(22494-47-9)核磁图(¹HNMR)

常见问题列表

生物活性

Clozic 是一种潜在的抗关节炎药物。

体外研究

Clozic is a potential anti-arthritic agent. Concentrations of Clozic greater than 50 μM cause a dose-dependent decrease in the amount of matrix protein synthesized by RHMC cell cultures. Inhibition of RHMC cell culture growth by Clozic occurs in a dose-dependent manner. The anti-proliferative effect of Clozic on RHMC cell growth is reversible. Lactate dehydrogenase (LDH) levels in media taken from RHMC cell cultures exposed to 500 μM Clozic for 3 days do not significantly differ from LDH levels in control cell culture media.