22550-15-8
中文名称
异隐丹参酮
英文名称
(8S)-1,2,3,4,8,9-Hexahydro-4,4,8-trimethylphenanthro[3,2-b]furan-7,11-dione
CAS
22550-15-8
分子式
C19H20O3
分子量
296.36
MOL 文件
22550-15-8.mol
更新日期
2023/08/07 15:35:42
22550-15-8 结构式
基本信息
中文别名
异隐丹参酮异丹参酮 III
英文别名
Isotanshinone IIIIsocryptotanshinone
(+)-1,2,3,4,8,9-Hexahydro-4,4,8-trimethylphenanthro[3,2-b]furan-7,11-dione
(8S)-1,2,3,4,8,9-Hexahydro-4,4,8-trimethylphenanthro[3,2-b]furan-7,11-dione
Phenanthro[3,2-b]furan-7,11-dione, 1,2,3,4,8,9-hexahydro-4,4,8-trimethyl-, (8S)-
所属类别
有机原料：酮类化合物常见问题列表
生物活性
Isocryptotanshinone 是一种有效的信号传导与转录激活因子3 (STAT3) 和蛋白酪氨酸磷酸酶1 B (PTP1B) 的抑制剂，其对 PTP1B 的 IC50 值为 56.1 μM。靶点
|
STAT3
|
PTP1B 56.1 μM (IC 50 ) |
体外研究
It is showed that tanshinones significantly inhibited A549 proliferation and Isocryptotanshinone (ICTS) exhibits the strongest activity. Isocryptotanshinone inhibits the constitutive STAT3 and p-STAT3 (Y705) expression in concentration and time-dependent manners. Isocryptotanshinone dramatically inhibits the IL-6-stimulated expression of p-STAT3 (Y705) in a time-dependent manner.