227321-12-2
中文名称
2,6-Dihydro-7-[(3-hydroxypropyl)thio]-2-methyl-4-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyridazin-1one
英文名称
2,6-Dihydro-7-[(3-hydroxypropyl)thio]-2-methyl-4-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyridazin-1one
CAS
227321-12-2
分子式
C25H29N3O2S
分子量
435.58
MOL 文件
227321-12-2.mol
更新日期
2024/10/23 12:41:44
227321-12-2 结构式
基本信息
中文别名
化合物 T26221 英文别名
SR 13800MCT1-IN-2
MCT-1-IN-2,MCT1 IN 2,MCT1IN2
2,6-Dihydro-7-[(3-hydroxypropyl)thio]-2-methyl-4-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyridazin-1one
物理化学性质
熔点152 °C
沸点642.8±65.0 °C(Predicted)
密度1.23±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)14.87±0.10(Predicted)
形态Solid
颜色White to off-white
常见问题列表
生物活性
MCT1-IN-2 是有效的单羧酸盐转运蛋白 1 (MCT1) 抑制剂。MCT1-IN-2 具有抗癌活性。体外研究
MCT1-IN-2 (compound 3) has a pK
i
of 9.48 for Jurkat T-cells and inhibits human peripheral blood mononuclear cells (PBMC) proliferation (pIC
50
=8.61).
MCT1-IN-2 (compound 1) has an EC
50
of 5.5 nM (MTT assay) and an IC
50
of 105 nM (lactate transport inhibition assay) in human Raji lymphoma cell proliferation.