2319790-02-6
2319790-02-6 结构式
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2023/01/06 | S3509 | SSD114 HYDROCHLORIDE SSD114 hydrochloride | 2319790-02-6 | 25mg | 4644.53元 |
| 2021/03/30 | S3509 | SSD114 HYDROCHLORIDE SSD114 hydrochloride | 2319790-02-6 | 5mg | 1548.79元 |
常见问题列表
GABA B receptor
In the presence of 10 µM GABA, SSD114 hydrochloride at 25 µM significantly increases (to approximately 170% above basal levels) the [ 35 S]GTPγS stimulation induced by GABA alone. SSD114 hydrochloride, added at 15 and 30 µM, induces a leftward shift of the GABA concentration-response curve with a slight concomitant increase of maximal GABA stimulation at the highest concentration. In the presence of both 15 and 30 µM SSD114 hydrochloride, the EC 50 for GABA decreases by 2 and 2.5 fold, respectively, while the maximal stimulation (Emax) is potentiated only at the concentration of 30 µM, reaching 161±5.09% over the basal value .
The onset of loss of righting reflex (LORR) is reduced by pretreatment with SSD114 hydrochloride [F (5,30) =4.55, P<0.005]. Post hoc analysis indicates that the onset of LORR is significantly lower in mouse groups pretreated with doses of SSD114 hydrochloride equal to or higher than 10 mg/kg than in vehicle-treated mice. The duration of LORR is increased by pretreatment with SSD114 hydrochloride [F (5,30) =4.81, P<0.005]. Post hoc analysis indicates that the duration of LORR is significantly longer in mouse groups pretreated with 10 and 100 mg/kg SSD114 hydrochloride than in vehicle-treated mice.