2320930-10-5

英文名称 SSM 3 trifluoroacetate

CAS 2320930-10-5

分子式 C24H33F3N12O4

分子量 610.6

MOL 文件 2320930-10-5.mol

2320930-10-5 结构式

基本信息物理化学性质常见问题列表

基本信息

英文别名

SSM3 tetraTFA

物理化学性质

储存条件-20°C储存

溶解度溶于二甲基亚砜

常见问题列表

生物活性

SSM3 tetraTFA 是一种有效的合成呋喃啉 (furin) 抑制剂，EC50 和 Ki 分别为 54 nM 和 12 nM。SSM3 tetraTFA 能阻断 furin 依赖的炭疽毒素保护 antigen-83 的细胞表面进程。

靶点

EC50: 54 nM (furin)Ki: 12 nM (furin)

体外研究

SSM3 tetraTFA is against furin cleavage of the Pyr-RTKR-AMC substrate with an EC ₅₀ of 54 nM in vitro cleavage assays and cell-based tests.SSM3 tetraTFA (0.1-25 μM) inhibits the furin-dependent conversion of PA83 into PA63 in a dose dependent manner, it inhibits PA83 processing in the cleavage reactions.SSM3 tetraTFA shows comparable potency against furin (K _i =0.012 μM) and PC6B (K _i =0.004 μM), these compounds preferentially inhibited furin over PACE4 (K _i =0.041 μM) by 2- to 10-fold and over PC7 (K _i =0.595 μM) by 11- to 76-fold. In addition, it inhibits LF (K _i =1.241 μM) 25- to 167-fold less effectively than in furin and shows no measurable inhibition against trypsin and MT1-MMP.