2349368-16-5

中文名称 Benzeneacetamide, 4-(ethylsulfonyl)-N-[2'-fluoro-4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]-

英文名称 Benzeneacetamide, 4-(ethylsulfonyl)-N-[2'-fluoro-4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]-

CAS 2349368-16-5

分子式 C25H20F7NO4S

分子量 563.48

MOL 文件 2349368-16-5.mol

2349368-16-5 结构式

基本信息物理化学性质应用领域 Benzeneacetamide, 4-(ethylsulfonyl)-N-[2'-fluoro-4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]-价格(试剂级)

基本信息

中文别名

XY101
化合物 T13362

英文别名

XY101
Benzeneacetamide, 4-(ethylsulfonyl)-N-[2'-fluoro-4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]-

物理化学性质

沸点682.4±55.0 °C(Predicted)

密度1.439±0.06 g/cm3(Predicted)

储存条件-20°C储存

溶解度DMSO: 250 mg/mL (443.67 mM)

酸度系数(pKa)8.87±0.19(Predicted)

形态Solid

颜色Off-white to light yellow

应用领域

用途一

XY101 is a Potent, Selective, and Orally Bioavailable RORγ Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer with IC50 = 30nM. XY101 potently inhibited cell growth, colony formation, and the expression of AR, AR-V7, and PSA. XY101 also exhibited good metabolic stability and a pharmacokinetic profile with oral bioavailability of 59% and a half-life of 7.3 h. Notably, XY101 demonstrated promising therapeutic effects with significant tumor growth inhibition in a prostate cancer xenograft model inmice.