2353492-68-7
英文名称
1H-Isoindole-1,3(2H)-dione, 4-[[2-[4-[1-[4-[[5-chloro-4-[[2-(dimethylphosphinyl)phenyl]amino]-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-piperidinyl]-1-piperazinyl]-2-oxoethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-
CAS
2353492-68-7
分子式
C43H48ClN10O7P
分子量
883.33
MOL 文件
2353492-68-7.mol
2353492-68-7 结构式
基本信息
英文别名
SIAIS1640181H-Isoindole-1,3(2H)-dione, 4-[[2-[4-[1-[4-[[5-chloro-4-[[2-(dimethylphosphinyl)phenyl]amino]-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-piperidinyl]-1-piperazinyl]-2-oxoethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-
应用领域
用途一
SIAIS164018 is a protein degrader. SIAIS164018 could degrade not only ALK fusion proteins in activating or G1202R-mutated form but also mutant EGFR with L858R + T790M, which are two most important targets in non-small-cell lung cancer. SIAIS164018 strongly inhibited cell migration and invasion of Calu-1 and MDA-MB-231. Surprisingly, SIAIS164018 degrades several important oncoproteins involved in metastasis such as FAK, PYK2, and PTK6. Interestingly, SIAIS164018 reshuffled the kinome ranking profile when compared to Brigatinib. SIAIS164018 is orally bioavailable and well tolerated in vivo. SIAIS164018 is an enlightening degrader for us to excavate the charm of protein degradation.