23555-00-2
中文名称
HOECHST 34580
英文名称
HOECHST 34580
CAS
23555-00-2
分子式
C27H29N7
分子量
451.57
MOL 文件
23555-00-2.mol
更新日期
2024/08/20 10:22:42
23555-00-2 结构式
基本信息
英文别名
ProaMineHOE 34580
HOECHST 34580
2,50-bibenzimidazole, 20-[p-(dimethylamino)phenyl]-5-(4-methyl-1-piperazinyl)-
Benzenamine, N,N-dimethyl-4-[5-(4-methyl-1-piperazinyl)[2,5'-bi-1H-benzimidazol]-2'-yl]-
所属类别
生物化工：荧光成像物理化学性质
熔点>300℃
储存条件Keep in dark place,Sealed in dry,2-8°C
溶解度溶于二甲亚砜、水
酸度系数(pKa)10.97±0.10, most acidic, temperature:
25 °C; 7.66 ± 0.42, most basic(at 25℃)
形态粉末
颜色黄色到绿色
最大波长(λmax)392nm
生物领域应用Detecting malaria infected red blood cells,polynucleotides; nucleic acid amplification; nucleic acid sequencing
HOECHST 34580价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/08/19 | S0486 | HOECHST 34580 Hoechst 34580 | 23555-00-2 | 5mg | 2047.06元 |
| 2024/08/19 | S0486 | HOECHST 34580 Hoechst 34580 | 23555-00-2 | 25mg | 6445.63元 |
| 2023/03/20 | HY-15560 | HOECHST 34580 Hoechst 34580 | 23555-00-2 | 5mg | 600元 |
常见问题列表
生物活性
Hoechst 34580 (HOE 34580) 是一种具有细胞渗透性的蓝色荧光染料，用于染色DNA和细胞核。Hoechst 34580 也是一种治疗阿尔茨海默病的良好候选者，通过抑制 amyloid beta (Aβ) 的形成，其IC50值为0.86 μM。靶点
| Target | Value |
|
Aβ
(Cell-free assay) | 0.86 μM |
体外研究
Hoechst 34580 prefers to locate near hydrophobic regions with binding affinity with the inhibition constant IC 50 of 0.86±0.05 μM for Hoechst 34580. Hoechst 34580 is a good candidate for treating the Alzheimer’s disease by inhibiting Aβ formation. 50 μM Aβ42 solutions co-incubated with 100, 25, 12.5, 3.125, 0.78, and 0.1, 0.01 μM Hoechst 34580 at 37 °C for 70 h. Hoechst 34580 can inhibit the aggregation of Aβ42 in a dose-dependent manner. And the half-maximal concentration (IC 50 ) is examined. The IC 50 is obtained by measuring the concentration of Hoechst 34580 while maintaining the Aβ42 concentration which gave 0.86±0.05 μM for Hoechst 34580.