常见问题列表
生物活性
TP-238 是一种有效的选择性的 CECR2/BPTF 双探针，pIC50 值分别为 7.5 和 6.5。TP-238 还抑制 BRD9，pIC50 为 5.9，对其他 338 种激酶的活性较低。靶点
|
CECR2 7.5 (pIC 50 ) |
BPTF 6.5 (pIC 50 ) |
BRD9 5.9 (pIC 50 ) |
体外研究
TP-238 (compound 4) has on target biochemical activity of 10-30 nM with CECR2 and 100-350 nM with BPTF. TP-238 shows an IC 50 of 30 nM against CECR2 and 350 nM against BPTF in an alphascreen assay. ITC shows TP-238 with a K d of 10 nM for CECR2 and 120 nM for BPTF.