2416095-00-4
英文名称
Glycine, N-[(3R,4S)-4-[(3,4-dichlorophenyl)sulfonyl]tetrahydro-1,1-dioxido-3-thienyl]-, rel-
CAS
2416095-00-4
分子式
C12H13Cl2NO6S2
分子量
402.27
MOL 文件
2416095-00-4.mol
2416095-00-4 结构式
基本信息
英文别名
CBR-470-2Glycine, N-[(3R,4S)-4-[(3,4-dichlorophenyl)sulfonyl]tetrahydro-1,1-dioxido-3-thienyl]-, rel-
物理化学性质
沸点734.1±60.0 °C(Predicted)
密度1.71±0.1 g/cm3(Predicted)
储存条件4°C, stored under nitrogen
溶解度DMSO: 200 mg/mL (497.18 mM)
酸度系数(pKa)2.34±0.10(Predicted)
形态Solid
颜色White to off-white
常见问题列表
生物活性
CBR-470-2 是甘氨酸取代的类似物，可以激活 NRF2 信号传导。CBR-470-2 可用于调节糖酵解。靶点
NRF2
体外研究
CBR-470-2 (1-10 μM; 24 h) increases transcript levels of the NRF2-responsive genes NQO1 and HMOX1 in epidermal keratinocytes and dermal fibroblasts.
体内研究
CBR-470-2 (50 mg/kg; p.o. twice daily for 10 d) induces activation of NRF2 signaling in vivo.
| Animal Model: | Balb/C mice (5-week old) are exposed to UVB |
| Dosage: | 50 mg/kg |
| Administration: | P.o. twice daily for 10 days |
| Result: |
Resulted in comparable beneficial effects on erythema histological scores and total wounded area.
Decreased epidermal thickness in response to UV exposure. |